Assay Detail
Functional
CHEMBL784182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The inhibitory concentration of compound against sodium dependent [3H]GABA synaptosomal uptake in rats
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and activity of 5-(aminomethylene)-1,3-cyclohexanediones: enolic analogues of gamma-aminobutyric acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.50 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL701 | BACLOFEN | 4.0 | 1 | 5.75 |
| CHEMBL277498 | NIPECOTIC ACID | — | 1 | 5.25 |
| CHEMBL32861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL701 | BACLOFEN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL277498 | NIPECOTIC ACID | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL32861 | — | IC50 | > | 100000.0 | nM | - |