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Assay Detail

CHEMBL785166

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Vasorelaxant potency required to relax methoxamine contracted male Wistar Kyoto rat thoracic aorta
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Thoracic aorta
Confidence 1 — Organism
Curated By Intermediate

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Aryl cyanoguanidine potassium channel openers
Atwal KS, Moreland S, McCullough JR, O'Reilly BC, Ahmed SZ, Normandin DE
Bioorg Med Chem Lett (1992) 2 : 83 -86
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.42 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL19169 1 7.66
CHEMBL49035 CROMAKALIM 2.0 1 7.26
CHEMBL1159 PINACIDIL ANHYDROUS 4.0 1 7.16
CHEMBL93196 1 6.92
CHEMBL169338 1 6.77
CHEMBL353113 1 6.62
CHEMBL93834 1 6.38
CHEMBL328082 1 6.37
CHEMBL93835 1 6.06
CHEMBL168404 1 5.82
CHEMBL435075 1 5.29
CHEMBL90665 1 4.72
CHEMBL90631 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL19169 IC50 = 22.0 nM 7.66
CHEMBL49035 CROMAKALIM IC50 = 55.0 nM 7.26
CHEMBL1159 PINACIDIL ANHYDROUS IC50 = 70.0 nM 7.16
CHEMBL93196 IC50 = 120.0 nM 6.92
CHEMBL169338 IC50 = 170.0 nM 6.77
CHEMBL353113 IC50 = 240.0 nM 6.62
CHEMBL93834 IC50 = 420.0 nM 6.38
CHEMBL328082 IC50 = 430.0 nM 6.37
CHEMBL93835 IC50 = 880.0 nM 6.06
CHEMBL168404 IC50 = 1500.0 nM 5.82
CHEMBL435075 IC50 = 5150.0 nM 5.29
CHEMBL90665 IC50 = 19000.0 nM 4.72
CHEMBL90631 IC50 = 123000.0 nM -