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Compound Detail

CHEMBL93196

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CCC(C)(C)/N=C(\NC#N)Nc1ccc(C#N)cc1

Basic Information

ChEMBL ID CHEMBL93196
Phase Preclinical
Structure Type MOL
InChI Key NMMSLDYACYCEND-UHFFFAOYSA-N
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

255.3
MW (Da)
2.59
ALogP
3
HBA
2
HBD
84.0
PSA (Ų)
0.38
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H17N5
MW 255.32
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness -1.20

Activity Summary

IC50 2 meas. best 6.92
Ki 1 meas. best 6.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Rattus norvegicus
CHEMBL376
IC50 6.92 6.905 120.0 2
Sulfonylurea receptor 2, Kir6.2
CHEMBL2095198
Ki 6.8 6.8 160.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9464357 10.1021/jm970762d Sulfonylurea receptor 2, Kir6.2 2
9464357 10.1021/jm970762d Rattus norvegicus 2
- 10.1016/S0960-894X(00)80661-7 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine