Assay Detail
Functional
CHEMBL872971
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Inhibitory concentration against methoxamine-induced contractions in rat aorta
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.67 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328308 | — | — | 1 | 8.85 |
| CHEMBL11458 | — | — | 1 | 8.36 |
| CHEMBL19169 | — | — | 1 | 7.52 |
| CHEMBL11684 | (-)-CROMAKALIM | — | 2 | 7.40 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 7.22 |
| CHEMBL93196 | — | — | 1 | 6.89 |
| CHEMBL93834 | — | — | 1 | 6.72 |
| CHEMBL328082 | — | — | 1 | 6.28 |
| CHEMBL93835 | — | — | 1 | 6.01 |
| CHEMBL96267 | — | — | 1 | 4.89 |
| CHEMBL90665 | — | — | 1 | 4.72 |
| CHEMBL90631 | — | — | 1 | - |
| CHEMBL327884 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328308 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL11458 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL19169 | — | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL11684 | (-)-CROMAKALIM | IC50 | = | 40.1 | nM | 7.40 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | IC50 | = | 59.6 | nM | 7.22 |
| CHEMBL93196 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL93834 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL328082 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL93835 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL11684 | (-)-CROMAKALIM | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL96267 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL90665 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL90631 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL327884 | — | IC50 | > | 30.0 | nM | - |