Assay Detail
Functional
CHEMBL785218
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Tested for antagonistic activity against ET-1 induced increase in intracellular [Ca2+] in VSM-A10 cells.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | VSM-A10 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.40 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453 | SULFISOXAZOLE | 4.0 | 1 | 4.40 |
| CHEMBL26630 | SULFATROXAZOLE | 2.0 | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453 | SULFISOXAZOLE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL26630 | SULFATROXAZOLE | IC50 | = | 40000.0 | nM | 4.40 |