Compound Detail
CHEMBL26630
SULFATROXAZOLE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL26630 |
| Name | SULFATROXAZOLE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | DAUFGBIKKGOPJA-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
2
Known Names
Molecular Properties
267.3
MW (Da)
1.67
ALogP
5
HBA
2
HBD
98.2
PSA (Ų)
0.82
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 4 meas. best 6.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelin-1 receptor CHEMBL4566 | IC50 | 6.58 | 6.1533 | 260.0 | 3 |
| Rattus norvegicus CHEMBL376 | IC50 | 4.4 | 4.4 | 40000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelin-1 receptor | IC50 | = | 260.0 | nM | 6.58 | Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smo... | 7731020 |
| Endothelin-1 receptor | IC50 | = | 260.0 | nM | 6.58 | Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoraci... | 7861414 |
| Endothelin-1 receptor | IC50 | = | 5000.0 | nM | 5.3 | Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfecte... | 10969989 |
| Rattus norvegicus | IC50 | = | 40000.0 | nM | 4.4 | Tested for antagonistic activity against ET-1 induced increase in intracellular ... | 7731020 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10969989 | 10.1016/s0960-894x(00)00366-8 | Endothelin-1 receptor | 1 |
| 10969989 | 10.1016/s0960-894x(00)00366-8 | Endothelin receptor type B | 1 |
| 7731020 | 10.1021/jm00008a013 | Endothelin-1 receptor | 1 |
| 7731020 | 10.1021/jm00008a013 | Rattus norvegicus | 1 |
| 7861414 | 10.1021/jm00004a012 | Endothelin-1 receptor | 1 |
Data from ChEMBL 36 via Core Engine