Assay Detail
Functional
CHEMBL785241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of K+ induced contractions of the isolated rat aorta.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-dependent L-type calcium channel subunit alpha-1C (CHEMBL3762) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 1. 2-(3, 5-di-tert-butyl-4-hydroxyphenyl)-3-(aminopropyl)thiazolidinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.36 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107949 | — | — | 1 | 7.21 |
| CHEMBL137151 | — | — | 1 | 7.03 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 7.00 |
| CHEMBL138800 | — | — | 1 | 6.92 |
| CHEMBL423535 | — | — | 1 | 6.75 |
| CHEMBL344472 | — | — | 1 | 6.70 |
| CHEMBL335343 | — | — | 1 | 6.68 |
| CHEMBL137172 | — | — | 1 | 6.64 |
| CHEMBL137094 | — | — | 1 | 6.64 |
| CHEMBL336705 | — | — | 1 | 6.60 |
| CHEMBL137352 | — | — | 1 | 6.52 |
| CHEMBL344252 | — | — | 1 | 6.38 |
| CHEMBL137324 | — | — | 1 | 6.37 |
| CHEMBL137436 | — | — | 1 | 6.22 |
| CHEMBL137009 | — | — | 1 | 6.12 |
| CHEMBL341710 | — | — | 1 | 6.08 |
| CHEMBL137390 | — | — | 1 | 5.92 |
| CHEMBL136357 | — | — | 1 | 5.82 |
| CHEMBL138484 | — | — | 1 | 5.77 |
| CHEMBL137514 | — | — | 1 | 5.62 |
| CHEMBL138126 | — | — | 1 | 5.48 |
| CHEMBL137426 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107949 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL137151 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL23 | DILTIAZEM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL138800 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL423535 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL344472 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL335343 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL137172 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL137094 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL336705 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL137352 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL344252 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL137324 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL137436 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL137009 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL341710 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL137390 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL136357 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL138484 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL137514 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL138126 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL137426 | — | IC50 | = | 4400.0 | nM | 5.36 |