Assay Detail
Functional
CHEMBL786460
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-HT reuptake from rat caudate using [3H]5-HT
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.26 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.14 |
| CHEMBL26320 | — | — | 1 | 6.54 |
| CHEMBL3084919 | — | — | 1 | 6.37 |
| CHEMBL3084920 | — | — | 1 | 6.24 |
| CHEMBL126235 | — | — | 1 | 5.39 |
| CHEMBL129193 | — | — | 1 | 5.30 |
| CHEMBL3084921 | — | — | 1 | 5.15 |
| CHEMBL130643 | — | — | 1 | 5.09 |
| CHEMBL3084922 | — | — | 1 | 4.92 |
| CHEMBL126735 | — | — | 1 | 4.85 |
| CHEMBL339614 | — | — | 1 | 4.77 |
| CHEMBL1201203 | BENZTROPINE | 4.0 | 1 | 4.73 |
| CHEMBL415721 | — | — | 1 | 4.22 |
| CHEMBL127053 | — | — | 1 | 4.22 |
| CHEMBL3084918 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL26320 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL3084919 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL3084920 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL126235 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL129193 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL3084921 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL130643 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL3084922 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL126735 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL339614 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL1201203 | BENZTROPINE | Ki | = | 18500.0 | nM | 4.73 |
| CHEMBL415721 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL127053 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL3084918 | — | Ki | = | 100000.0 | nM | 4.00 |