Assay Detail
Functional
CHEMBL789047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to rat corpus striatum was determined using [3H]NPA as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
6,7-Dihydroxy-3-chromanamine: synthesis and pharmacological activity of an oxygen isostere of the dopamine agonist 6,7-dihydroxy-2-aminotetralin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.58 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.98 |
| CHEMBL26736 | — | — | 1 | 7.92 |
| CHEMBL26730 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL26736 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL26730 | — | Ki | = | 144.0 | nM | 6.84 |