Compound Detail
CHEMBL26730
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Basic Information
| ChEMBL ID | CHEMBL26730 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OVHHRQKKSBBVQF-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
181.2
MW (Da)
0.36
ALogP
4
HBA
3
HBD
75.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.59
Ki 1 meas. best 6.84
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | Ki | 6.84 | 6.84 | 144.0 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 6.59 | 6.59 | 259.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | Ki | = | 144.0 | nM | 6.84 | Binding affinity to rat corpus striatum was determined using [3H]NPA as radiolig... | 6090664 |
| Rattus norvegicus | IC50 | = | 259.0 | nM | 6.59 | Concentration required to reduce the specific binding of [3H]NPA by 50% to rat c... | 6090664 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6090664 | 10.1021/jm00376a020 | Rattus norvegicus | 13 |
| 6090664 | 10.1021/jm00376a020 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine