Assay Detail
Functional
CHEMBL790107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant of compound on R-(+)-125[I]-8 radioligand binding to rat striatal membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and resolution of (+-)-7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro- 1H-3- benzazepine (TISCH): a high affinity and selective iodinated ligand for CNS D1 dopamine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.81 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.55 |
| CHEMBL172352 | — | — | 1 | 8.97 |
| CHEMBL1255588 | — | — | 1 | 8.28 |
| CHEMBL25554 | — | — | 1 | 6.20 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 6.07 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | - |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | - |
| CHEMBL80 | NALOXONE | 4.0 | 1 | - |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL172352 | — | Ki | = | 1.07 | nM | 8.97 |
| CHEMBL1255588 | — | Ki | = | 5.26 | nM | 8.28 |
| CHEMBL25554 | — | Ki | = | 634.0 | nM | 6.20 |
| CHEMBL267930 | SPIPERONE | Ki | = | 849.0 | nM | 6.07 |
| CHEMBL39 | SEROTONIN | Ki | > | 5000.0 | nM | - |
| CHEMBL59 | DOPAMINE | Ki | > | 3000.0 | nM | - |
| CHEMBL80 | NALOXONE | Ki | > | 6000.0 | nM | - |
| CHEMBL27 | PROPRANOLOL | Ki | > | 5000.0 | nM | - |