Assay Detail
Functional
CHEMBL792299
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Binding of [3H]diprenorphine to rat brain membranes was evaluated and the dissociation constant (KD) was determined.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N-(3-[18F]fluoropropyl)-N-nordiprenorphine: synthesis and characterization of a new agent for imaging opioid receptors with positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 9.11 | 10.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311186 | — | — | 1 | 10.33 |
| CHEMBL281786 | DIPRENORPHINE | 2.0 | 1 | 9.00 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311186 | — | Kd | = | 0.047 | nM | 10.33 |
| CHEMBL281786 | DIPRENORPHINE | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL80 | NALOXONE | Kd | = | 10.0 | nM | 8.00 |