Assay Detail
Functional
CHEMBL793161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for alpha-adrenoceptor blocking activity by its ability to antagonize norepinephrine contraction in the rat thoracic aorta
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrimidine derivatives. 4. Synthesis and antihypertensive activity of 4-amino-2-(4-cinnamoylpiperazino)-6,7-dimethoxyquinazoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 9.20 | 10.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1558 | PRAZOSIN HYDROCHLORIDE | 4.0 | 1 | 10.29 |
| CHEMBL538288 | — | — | 1 | 9.85 |
| CHEMBL268768 | — | — | 1 | 9.14 |
| CHEMBL135797 | — | — | 1 | 8.66 |
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1558 | PRAZOSIN HYDROCHLORIDE | Kd | = | 0.05129 | nM | 10.29 |
| CHEMBL538288 | — | Kd | = | 0.1413 | nM | 9.85 |
| CHEMBL268768 | — | Kd | = | 0.7244 | nM | 9.14 |
| CHEMBL135797 | — | Kd | = | 2.188 | nM | 8.66 |
| CHEMBL597 | PHENTOLAMINE | Kd | = | 8.511 | nM | 8.07 |