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Assay Detail

CHEMBL796069

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vivo pA2 value represent the negative logarithm of the effective dose divided by the estimated volume of distribution (67 mL/kg).
20
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Design of more potent antagonists of the antidiuretic responses to arginine-vasopressin.
Manning M, Olma A, Klis WA, Kolodziejczyk AM, Seto J, Sawyer WH.
J Med Chem (1982) 25 : 45 -50
PubMed 7086821 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 20 7.87 8.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2370971 2 8.48
CHEMBL2370977 2 8.41
CHEMBL2370970 2 8.40
CHEMBL2370976 2 8.22
CHEMBL2370975 2 8.19
CHEMBL2370978 2 8.14
CHEMBL553710 3 8.05
CHEMBL2370973 2 7.92
CHEMBL2370972 2 7.88
CHEMBL2370974 1 7.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2370971 Kd = 3.311 nM 8.48
CHEMBL2370977 Kd = 3.89 nM 8.41
CHEMBL2370970 Kd = 3.981 nM 8.40
CHEMBL2370976 Kd = 6.026 nM 8.22
CHEMBL2370975 Kd = 6.457 nM 8.19
CHEMBL2370978 Kd = 7.244 nM 8.14
CHEMBL553710 Kd = 8.913 nM 8.05
CHEMBL553710 Kd = 10.72 nM 7.97
CHEMBL2370973 Kd = 12.02 nM 7.92
CHEMBL2370972 Kd = 13.18 nM 7.88
CHEMBL2370976 Kd = 15.49 nM 7.81
CHEMBL2370971 Kd = 16.98 nM 7.77
CHEMBL2370974 Kd = 20.89 nM 7.68
CHEMBL2370970 Kd = 21.88 nM 7.66
CHEMBL2370978 Kd = 24.55 nM 7.61
CHEMBL2370973 Kd = 25.12 nM 7.60
CHEMBL2370972 Kd = 25.7 nM 7.59
CHEMBL2370975 Kd = 30.9 nM 7.51
CHEMBL2370977 Kd = 30.9 nM 7.51
CHEMBL553710 Kd = 93.33 nM 7.03