Assay Detail
Functional
CHEMBL796735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]spiroperidol binding to rat striatal membrane using 0.5 nM ligand.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
4a,9b-trans-8-Fluoro-5-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole hydrochloride, a new potent neuroleptic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.61 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57241 | FLUTROLINE | 2.0 | 1 | 7.85 |
| CHEMBL175301 | — | — | 1 | 7.66 |
| CHEMBL174762 | — | — | 1 | 7.64 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57241 | FLUTROLINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL175301 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL174762 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 51.0 | nM | 7.29 |