Assay Detail
Functional
CHEMBL796743
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Inhibition constant on radiolabeled [125 I] FIDA2 binding to rat striatal membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.32 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 10.52 |
| CHEMBL1255588 | — | — | 1 | 9.40 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 6.30 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.28 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 5.10 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | - |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | - |
| CHEMBL80 | NALOXONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL1255588 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 505.0 | nM | 6.30 |
| CHEMBL59 | DOPAMINE | Ki | = | 5268.0 | nM | 5.28 |
| CHEMBL240773 | QUINPIROLE | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL517712 | ATROPINE | Ki | > | 10000.0 | nM | - |
| CHEMBL39 | SEROTONIN | Ki | > | 3000.0 | nM | - |
| CHEMBL80 | NALOXONE | Ki | > | 10000.0 | nM | - |