Assay Detail
Functional
CHEMBL796883
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Inhibition of [Ca2+] induced contraction of K+ depolarized rat aorta by 50%
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel heterocyclic analogues of the new potent class of calcium entry blockers: 1-[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.43 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 8.92 |
| CHEMBL34685 | — | — | 1 | 8.72 |
| CHEMBL33620 | — | — | 1 | 8.43 |
| CHEMBL31082 | — | — | 1 | 8.43 |
| CHEMBL287679 | — | — | 1 | 8.37 |
| CHEMBL285855 | FANTOFARONE | 2.0 | 1 | 8.25 |
| CHEMBL33344 | — | — | 1 | 8.24 |
| CHEMBL32989 | — | — | 1 | 8.23 |
| CHEMBL30440 | — | — | 1 | 7.88 |
| CHEMBL33326 | — | — | 1 | 7.84 |
| CHEMBL34509 | — | — | 1 | 7.79 |
| CHEMBL33001 | — | — | 1 | 7.77 |
| CHEMBL33293 | — | — | 1 | 7.73 |
| CHEMBL30535 | — | — | 1 | 7.72 |
| CHEMBL34058 | — | — | 1 | 7.70 |
| CHEMBL33072 | — | — | 1 | 7.62 |
| CHEMBL33738 | — | — | 1 | 7.51 |
| CHEMBL33560 | — | — | 1 | 7.48 |
| CHEMBL34450 | — | — | 1 | 7.43 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 7.33 |
| CHEMBL417136 | — | — | 1 | 7.29 |
| CHEMBL281749 | — | — | 1 | 7.26 |
| CHEMBL30321 | — | — | 1 | 7.08 |
| CHEMBL34100 | — | — | 1 | 7.08 |
| CHEMBL418045 | — | — | 1 | 7.00 |
| CHEMBL33740 | — | — | 1 | 6.92 |
| CHEMBL33497 | — | — | 1 | 6.78 |
| CHEMBL33735 | — | — | 1 | 6.70 |
| CHEMBL33559 | — | — | 1 | 6.64 |
| CHEMBL30954 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL34685 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL33620 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL31082 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL287679 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL285855 | FANTOFARONE | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL33344 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL32989 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL30440 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL33326 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL34509 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL33001 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL33293 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL30535 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL34058 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL33072 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL33738 | — | IC50 | = | 31.1 | nM | 7.51 |
| CHEMBL33560 | — | IC50 | = | 32.9 | nM | 7.48 |
| CHEMBL34450 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 47.1 | nM | 7.33 |
| CHEMBL417136 | — | IC50 | = | 50.8 | nM | 7.29 |
| CHEMBL281749 | — | IC50 | = | 55.1 | nM | 7.26 |
| CHEMBL30321 | — | IC50 | = | 84.2 | nM | 7.08 |
| CHEMBL34100 | — | IC50 | = | 84.2 | nM | 7.08 |
| CHEMBL418045 | — | IC50 | = | 99.3 | nM | 7.00 |
| CHEMBL33740 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL33497 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL33735 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL33559 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL30954 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL23 | DILTIAZEM | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL33531 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL34508 | — | IC50 | = | 1719.0 | nM | 5.76 |
| CHEMBL30585 | — | IC50 | = | 5056.0 | nM | 5.30 |