Assay Detail
Functional
CHEMBL796891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
inhibitory effect of compound on contraction induced by high potassium in isolated rat aorta
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A new class of calcium antagonists. 2. Synthesis and biological activity of 11-[[4-[4-(4-fluorophenyl)-1-piperazinyl]butyryl]amino]-6,11- dihydrodibenzo[b,e]-thiepin maleate and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.19 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1744305 | MONATEPIL MALEATE | -1.0 | 1 | 7.68 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1744305 | MONATEPIL MALEATE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL23 | DILTIAZEM | IC50 | = | 203.0 | nM | 6.69 |