Assay Detail
Functional
CHEMBL797959
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Ability to inhibit the uptake of norepinephrine [3H]-NE in to rat brain synaptosomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Asymmetric synthesis and pharmacology of methylphenidate and its para-substituted derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.77 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350236 | — | — | 1 | 8.03 |
| CHEMBL356030 | — | — | 1 | 7.14 |
| CHEMBL827 | DEXMETHYLPHENIDATE | 4.0 | 1 | 6.89 |
| CHEMBL796 | METHYLPHENIDATE | 4.0 | 1 | 6.77 |
| CHEMBL423234 | — | — | 1 | 6.61 |
| CHEMBL290634 | — | — | 1 | 6.06 |
| CHEMBL422343 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350236 | — | IC50 | = | 9.34 | nM | 8.03 |
| CHEMBL356030 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL827 | DEXMETHYLPHENIDATE | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL796 | METHYLPHENIDATE | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL423234 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL290634 | — | IC50 | = | 876.0 | nM | 6.06 |
| CHEMBL422343 | — | IC50 | = | 1305.0 | nM | 5.88 |