Assay Detail
Functional
CHEMBL797961
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In vitro inhibition of dopamine (DA) uptake in synaptosomal preparation of rat brain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
(2S,3S,5R)-2-(3,5-difluorophenyl)-3,5-dimethyl-2-morpholinol: a novel antidepressant agent and selective inhibitor of norepinephrine uptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.12 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273575 | NOMIFENSINE | 4.0 | 1 | 6.30 |
| CHEMBL894 | BUPROPION | 4.0 | 1 | 6.05 |
| CHEMBL115794 | MANIFAXINE | 2.0 | 1 | 6.00 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273575 | NOMIFENSINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL894 | BUPROPION | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL115794 | MANIFAXINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL11 | IMIPRAMINE | IC50 | > | 10000.0 | nM | - |