Compound Detail
CHEMBL115794
MANIFAXINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL115794 |
| Name | MANIFAXINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | OZGPVYJHWWPEFT-RGNHYFCHSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
2
Known Names
Molecular Properties
243.2
MW (Da)
1.51
ALogP
3
HBA
2
HBD
41.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 2 meas. best 7.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | IC50 | 7.16 | 6.58 | 70.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | IC50 | = | 70.0 | nM | 7.16 | In vitro inhibition of norepinephrine (NE) uptake in synaptosomal preparation of... | 8558500 |
| Rattus norvegicus | IC50 | = | 1000.0 | nM | 6.0 | In vitro inhibition of dopamine (DA) uptake in synaptosomal preparation of rat b... | 8558500 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8558500 | 10.1021/jm950630p | Rattus norvegicus | 4 |
| 8558500 | 10.1021/jm950630p | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine