Assay Detail
Functional
CHEMBL798099
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Determined for potency (muscarinic agonistic activity) expressed in superior cervical ganglion in vitro
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Superior cervical ganglion |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and characterization of all four isomers of the muscarinic agonist 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.46 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12587 | MUSCARINE | — | 1 | 6.77 |
| CHEMBL38756 | — | — | 2 | 5.25 |
| CHEMBL367128 | — | — | 1 | 5.24 |
| CHEMBL291280 | — | — | 2 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12587 | MUSCARINE | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL38756 | — | EC50 | = | 5623.41 | nM | 5.25 |
| CHEMBL367128 | — | EC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL291280 | — | EC50 | = | 27542.29 | nM | 4.56 |
| CHEMBL38756 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL291280 | — | EC50 | < | 100000.0 | nM | - |