Assay Detail
Functional
CHEMBL798113
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Tested for relaxation of rat aorta smooth muscle precontracted with 30 mM KCI by 50%, activity expresses as negative logarithm of molar concentration
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N,N-disubstituted benzopyran-4-(N-cyano)carboxamidines, cromakalim analogs with selective activity for guinea pig trachealis
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.76 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13571 | — | — | 1 | 7.82 |
| CHEMBL275973 | — | — | 1 | 7.05 |
| CHEMBL11684 | (-)-CROMAKALIM | — | 1 | 6.77 |
| CHEMBL13613 | — | — | 1 | 6.47 |
| CHEMBL1563246 | — | — | 1 | 6.28 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 6.14 |
| CHEMBL275243 | — | — | 1 | - |
| CHEMBL269157 | — | — | 1 | - |
| CHEMBL263879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13571 | — | EC50 | = | 15.14 | nM | 7.82 |
| CHEMBL275973 | — | EC50 | = | 89.13 | nM | 7.05 |
| CHEMBL11684 | (-)-CROMAKALIM | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL13613 | — | EC50 | = | 338.84 | nM | 6.47 |
| CHEMBL1563246 | — | EC50 | = | 524.81 | nM | 6.28 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | EC50 | = | 724.44 | nM | 6.14 |
| CHEMBL275243 | — | EC50 | < | 31622.78 | nM | - |
| CHEMBL269157 | — | EC50 | < | 31622.78 | nM | - |
| CHEMBL263879 | — | EC50 | < | 31622.78 | nM | - |