Assay Detail
Functional
CHEMBL798150
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity for retinoic acid receptor RAR beta in transcriptional activation assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acids
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.12 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275311 | — | — | 1 | 8.52 |
| CHEMBL93538 | — | — | 1 | 7.54 |
| CHEMBL93577 | — | — | 1 | 7.34 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.30 |
| CHEMBL91718 | — | — | 1 | 7.25 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 7.10 |
| CHEMBL328481 | — | — | 1 | 6.66 |
| CHEMBL32505 | — | — | 1 | 6.64 |
| CHEMBL93628 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275311 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL93538 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL93577 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL91718 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL38 | TRETINOIN | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL328481 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL32505 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL93628 | — | EC50 | = | 1990.0 | nM | 5.70 |