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Compound Detail

CHEMBL328481

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C/C(=C\c1ncc(C(=O)O)s1)c1cc2c(cc1C)C(C)(C)CCC2(C)C

Basic Information

ChEMBL ID CHEMBL328481
Phase Preclinical
Structure Type MOL
InChI Key WGOHVXKUHRUIRK-GXDHUFHOSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

369.5
MW (Da)
6.06
ALogP
3
HBA
1
HBD
50.2
PSA (Ų)
0.72
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H27NO2S
MW 369.53
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.05

Activity Summary

EC50 5 meas. best 8.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Retinoic acid receptor RXR-beta
CHEMBL1870
EC50 8.52 8.52 3.0 1
Retinoic acid receptor RXR-gamma
CHEMBL2004
EC50 8.4 8.4 4.0 1
Retinoic acid receptor RXR-alpha
CHEMBL2061
EC50 8.4 8.4 4.0 1
Retinoic acid receptor gamma
CHEMBL2003
EC50 6.7 6.7 200.0 1
Retinoic acid receptor beta
CHEMBL2008
EC50 6.66 6.66 220.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor alpha 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor beta 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor gamma 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-alpha 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-beta 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-gamma 1

Data from ChEMBL 36 via Core Engine