Assay Detail
Functional
CHEMBL807691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity for retinoic acid receptor RAR gamma in transcriptional activation assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acids
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.30 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275311 | — | — | 1 | 8.70 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.00 |
| CHEMBL93538 | — | — | 1 | 7.82 |
| CHEMBL93577 | — | — | 1 | 7.47 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.35 |
| CHEMBL91718 | — | — | 1 | 6.88 |
| CHEMBL32505 | — | — | 1 | 6.75 |
| CHEMBL328481 | — | — | 1 | 6.70 |
| CHEMBL93628 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275311 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL38 | TRETINOIN | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL93538 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL93577 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL91718 | — | EC50 | = | 131.0 | nM | 6.88 |
| CHEMBL32505 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL328481 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL93628 | — | EC50 | = | 979.0 | nM | 6.01 |