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Compound Detail

CHEMBL93577

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C/C(=C\c1ncc(C(=O)O)s1)c1ccc2c(c1)C(C)(C)CCC2(C)C

Basic Information

ChEMBL ID CHEMBL93577
Phase Preclinical
Structure Type MOL
InChI Key NXPNPFPVJPLLLG-JLHYYAGUSA-N
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

355.5
MW (Da)
5.75
ALogP
3
HBA
1
HBD
50.2
PSA (Ų)
0.76
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H25NO2S
MW 355.50
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.02

Activity Summary

EC50 6 meas. best 7.47

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Retinoic acid receptor gamma
CHEMBL2003
EC50 7.47 7.47 34.0 1
Retinoic acid receptor beta
CHEMBL2008
EC50 7.34 7.34 46.0 1
Retinoic acid receptor RXR-gamma
CHEMBL2004
EC50 6.8 6.8 160.0 1
Retinoic acid receptor RXR-beta
CHEMBL1870
EC50 6.68 6.68 210.0 1
Retinoic acid receptor alpha
CHEMBL2055
EC50 6.68 6.68 210.0 1
Retinoic acid receptor RXR-alpha
CHEMBL2061
EC50 6.68 6.68 210.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor alpha 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor beta 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor gamma 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-alpha 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-beta 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-gamma 1

Data from ChEMBL 36 via Core Engine