Assay Detail
Functional
CHEMBL798963
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity for retinoic acid receptor RXR gamma in transcriptional activation assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acids
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.78 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328481 | — | — | 1 | 8.40 |
| CHEMBL91718 | — | — | 1 | 7.48 |
| CHEMBL433178 | — | — | 1 | 7.07 |
| CHEMBL93628 | — | — | 1 | 6.98 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 6.85 |
| CHEMBL93577 | — | — | 1 | 6.80 |
| CHEMBL329802 | — | — | 1 | 6.77 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 5.96 |
| CHEMBL32505 | — | — | 1 | 5.82 |
| CHEMBL93538 | — | — | 1 | 5.64 |
| CHEMBL275311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328481 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL91718 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL433178 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL93628 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL93577 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL329802 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL38 | TRETINOIN | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL32505 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL93538 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL275311 | — | EC50 | - | nM | - |