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Compound Detail

CHEMBL433178

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C/C(=C\c1ncc(C(=O)O)n1S(=O)(=O)N(C)C)c1cc2c(cc1C)C(C)(C)CCC2(C)C

Basic Information

ChEMBL ID CHEMBL433178
Phase Preclinical
Structure Type MOL
InChI Key BLALMZNPJBBFCN-FOWTUZBSSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

459.6
MW (Da)
4.45
ALogP
5
HBA
1
HBD
92.5
PSA (Ų)
0.71
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H33N3O4S
MW 459.61
Aromatic Rings 2
Heavy Atoms 32
NP-Likeness -0.26

Activity Summary

EC50 3 meas. best 7.23

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Retinoic acid receptor RXR-alpha
CHEMBL2061
EC50 7.23 7.23 59.0 1
Retinoic acid receptor RXR-gamma
CHEMBL2004
EC50 7.07 7.07 86.0 1
Retinoic acid receptor RXR-beta
CHEMBL1870
EC50 6.75 6.75 180.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor alpha 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor beta 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor gamma 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-alpha 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-beta 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-gamma 1

Data from ChEMBL 36 via Core Engine