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Compound Detail

CHEMBL329802

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C/C(=C\c1nc(C(=O)O)c[nH]1)c1cc2c(cc1C)C(C)(C)CCC2(C)C

Basic Information

ChEMBL ID CHEMBL329802
Phase Preclinical
Structure Type MOL
InChI Key DYDVTRMDNGTYGL-GXDHUFHOSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

352.5
MW (Da)
5.33
ALogP
2
HBA
2
HBD
66.0
PSA (Ų)
0.78
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H28N2O2
MW 352.48
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness 0.20

Activity Summary

EC50 3 meas. best 7.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Retinoic acid receptor RXR-alpha
CHEMBL2061
EC50 7.05 7.05 89.0 1
Retinoic acid receptor RXR-beta
CHEMBL1870
EC50 6.89 6.89 130.0 1
Retinoic acid receptor RXR-gamma
CHEMBL2004
EC50 6.77 6.77 170.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor alpha 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor beta 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor gamma 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-alpha 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-beta 1
- 10.1016/0960-894X(95)00455-3 Retinoic acid receptor RXR-gamma 1

Data from ChEMBL 36 via Core Engine