Assay Detail
Functional
CHEMBL798364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of glutamate induced neuronal death in primary cultures of rat hippocampal neurons.
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Hippocampus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.41 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420289 | — | — | 1 | 8.89 |
| CHEMBL107075 | — | — | 1 | 8.70 |
| CHEMBL107104 | — | — | 1 | 8.57 |
| CHEMBL108120 | — | — | 1 | 8.40 |
| CHEMBL17350 | TRAXOPRODIL | 2.0 | 2 | 7.99 |
| CHEMBL321758 | — | — | 1 | 7.96 |
| CHEMBL105870 | — | — | 1 | 7.80 |
| CHEMBL319706 | (S)-IFENPRODIL | — | 1 | 7.26 |
| CHEMBL107055 | — | — | 1 | 7.24 |
| CHEMBL107148 | — | — | 1 | 7.20 |
| CHEMBL104314 | — | — | 1 | 7.17 |
| CHEMBL49623 | (R,S)-IFENPRODIL | — | 1 | 6.58 |
| CHEMBL106191 | — | — | 1 | 6.00 |
| CHEMBL321428 | — | — | 1 | 5.89 |
| CHEMBL262807 | — | — | 1 | 5.00 |
| CHEMBL102212 | — | — | 1 | - |
| CHEMBL106650 | — | — | 1 | - |
| CHEMBL431867 | — | — | 1 | - |
| CHEMBL109121 | — | — | 1 | - |
| CHEMBL107303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420289 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL107075 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL107104 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL108120 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL17350 | TRAXOPRODIL | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL17350 | TRAXOPRODIL | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL321758 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL105870 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL319706 | (S)-IFENPRODIL | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL107055 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL107148 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL104314 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL49623 | (R,S)-IFENPRODIL | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL106191 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL321428 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL262807 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL102212 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL106650 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL431867 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL109121 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL107303 | — | IC50 | > | 1000.0 | nM | - |