Assay Detail
Functional
CHEMBL798757
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Compound was tested for electrophysiological experiments using rat cortical wedge preparation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.85 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 5.46 |
| CHEMBL279956 | QUISQUALATE | — | 1 | 5.14 |
| CHEMBL315663 | — | — | 1 | 4.77 |
| CHEMBL71073 | — | — | 1 | 4.68 |
| CHEMBL73698 | — | — | 1 | 4.64 |
| CHEMBL10339 | — | — | 1 | 4.43 |
| CHEMBL173847 | — | — | 1 | - |
| CHEMBL73069 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL279956 | QUISQUALATE | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL315663 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL71073 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL73698 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL10339 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL173847 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL73069 | — | EC50 | > | 1000000.0 | nM | - |