Assay Detail
Functional
CHEMBL798760
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Spontaneous relaxant activity in rat aorta precontracted with 30 mM KCl
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Substituent effects of benzopyran-4-(N-cyano)-carboxamidine potassium channel openers for selectivity to guinea pig trachealis
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.09 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13928 | — | — | 1 | 7.97 |
| CHEMBL61823 | — | — | 1 | 6.89 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.77 |
| CHEMBL1563246 | — | — | 1 | 6.28 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 6.14 |
| CHEMBL264613 | — | — | 1 | 6.02 |
| CHEMBL60236 | — | — | 1 | 5.48 |
| CHEMBL417395 | — | — | 1 | 5.30 |
| CHEMBL431752 | — | — | 1 | 5.19 |
| CHEMBL60193 | — | — | 1 | 4.90 |
| CHEMBL303967 | — | — | 1 | - |
| CHEMBL60604 | — | — | 1 | - |
| CHEMBL59657 | — | — | 1 | - |
| CHEMBL269157 | — | — | 1 | - |
| CHEMBL294524 | — | — | 1 | - |
| CHEMBL60134 | — | — | 1 | - |
| CHEMBL59658 | — | — | 1 | - |
| CHEMBL292880 | — | — | 1 | - |
| CHEMBL60288 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13928 | — | EC50 | = | 10.72 | nM | 7.97 |
| CHEMBL61823 | — | EC50 | = | 128.82 | nM | 6.89 |
| CHEMBL49035 | CROMAKALIM | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL1563246 | — | EC50 | = | 524.81 | nM | 6.28 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | EC50 | = | 724.44 | nM | 6.14 |
| CHEMBL264613 | — | EC50 | = | 954.99 | nM | 6.02 |
| CHEMBL60236 | — | EC50 | = | 3311.31 | nM | 5.48 |
| CHEMBL417395 | — | EC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL431752 | — | EC50 | = | 6456.54 | nM | 5.19 |
| CHEMBL60193 | — | EC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL303967 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL60604 | — | EC50 | > | 31622.78 | nM | - |
| CHEMBL59657 | — | EC50 | > | 31622.78 | nM | - |
| CHEMBL269157 | — | EC50 | > | 31622.78 | nM | - |
| CHEMBL294524 | — | EC50 | > | 31622.78 | nM | - |
| CHEMBL60134 | — | EC50 | > | 31622.78 | nM | - |
| CHEMBL59658 | — | EC50 | > | 31622.78 | nM | - |
| CHEMBL292880 | — | EC50 | > | 31622.78 | nM | - |
| CHEMBL60288 | — | EC50 | > | 31622.78 | nM | - |