Assay Detail
Binding
CHEMBL798975
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Inhibition of Serine/threonine protein phosphatase 1 by anhydride modified Cantharidin analogues
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (CHEMBL4438) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.53 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 5.75 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 5.70 |
| CHEMBL16701 | — | — | 1 | 5.53 |
| CHEMBL278014 | — | — | 1 | 5.33 |
| CHEMBL17154 | — | — | 1 | 5.32 |
| CHEMBL298459 | — | — | 1 | - |
| CHEMBL47461 | — | — | 1 | - |
| CHEMBL45742 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL16701 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL278014 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL17154 | — | IC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL298459 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL47461 | — | IC50 | = | 746000.0 | nM | - |
| CHEMBL45742 | — | IC50 | > | 1000000.0 | nM | - |