Assay Detail
Binding
CHEMBL798983
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Concentration required to inhibit the action of protein phosphatase 2A
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine-threonine protein phosphatase 2A regulatory subunit (CHEMBL2669) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
The first two cantharidin analogues displaying PP1 selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.64 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 5.77 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 5.68 |
| CHEMBL1552183 | FOSTRIECIN SODIUM | 2.0 | 1 | 5.47 |
| CHEMBL126291 | — | — | 1 | - |
| CHEMBL129709 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1552183 | FOSTRIECIN SODIUM | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL126291 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL129709 | — | IC50 | = | 426000.0 | nM | - |