Compound Detail
CHEMBL1552183
FOSTRIECIN SODIUM 🧪 Phase II
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🧪 Phase II
C[C@@](O)(/C=C/[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)/C=C\C=C/C=C/CO)OP(=O)([O-])O.[Na+]
Basic Information
| ChEMBL ID | CHEMBL1552183 |
| Name | FOSTRIECIN SODIUM |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | XBUIKNRVGYFSHL-IAVQPKKASA-M |
| Parent Compound | CHEMBL17377 |
| Active Moiety | CHEMBL17377 |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
2
Known Names
Molecular Properties
430.4
MW (Da)
1.06
ALogP
7
HBA
5
HBD
153.8
PSA (Ų)
0.14
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 2 meas. best 5.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine-threonine protein phosphatase 2A regulatory subunit CHEMBL2669 | IC50 | 5.47 | 5.47 | 3400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine-threonine protein phosphatase 2A regulatory subunit | IC50 | = | 3400.0 | nM | 5.47 | Concentration required to inhibit the action of protein phosphatase 2A | 11814804 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11814804 | 10.1016/s0960-894x(01)00777-6 | Unchecked | 2 |
| 11814804 | 10.1016/s0960-894x(01)00777-6 | Serine-threonine protein phosphatase 2A regulatory subunit | 1 |
Data from ChEMBL 36 via Core Engine