Assay Detail
Binding
CHEMBL799495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in Y272F
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (CHEMBL4438) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.21 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444092 | MICROCYSTIN-LR | — | 1 | 9.10 |
| CHEMBL430266 | CALYCULIN A | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444092 | MICROCYSTIN-LR | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL430266 | CALYCULIN A | IC50 | = | 48.0 | nM | 7.32 |