Assay Detail
Functional
CHEMBL799759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antivasopressor activity in rats.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of more potent and selective antagonists of the antidiuretic responses to arginine-vasopressin devoid of antidiuretic agonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 7.15 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2370977 | — | — | 1 | 8.41 |
| CHEMBL3349848 | — | — | 1 | 8.06 |
| CHEMBL3349849 | — | — | 1 | 8.05 |
| CHEMBL3349851 | — | — | 1 | 7.98 |
| CHEMBL553710 | — | — | 1 | 7.97 |
| CHEMBL3349504 | — | — | 1 | 6.94 |
| CHEMBL3349855 | — | — | 1 | 6.45 |
| CHEMBL3349854 | — | — | 1 | 6.41 |
| CHEMBL3349853 | — | — | 1 | 5.79 |
| CHEMBL3349850 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2370977 | — | Kd | = | 3.89 | nM | 8.41 |
| CHEMBL3349848 | — | Kd | = | 8.71 | nM | 8.06 |
| CHEMBL3349849 | — | Kd | = | 8.913 | nM | 8.05 |
| CHEMBL3349851 | — | Kd | = | 10.47 | nM | 7.98 |
| CHEMBL553710 | — | Kd | = | 10.72 | nM | 7.97 |
| CHEMBL3349504 | — | Kd | = | 114.82 | nM | 6.94 |
| CHEMBL3349855 | — | Kd | = | 354.81 | nM | 6.45 |
| CHEMBL3349854 | — | Kd | = | 389.05 | nM | 6.41 |
| CHEMBL3349853 | — | Kd | = | 1621.81 | nM | 5.79 |
| CHEMBL3349850 | — | Kd | = | 3981.07 | nM | 5.40 |