Assay Detail
Binding
CHEMBL801199
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Binding affinity of [3H]citalopram for serotonin transporter in monkey
11
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.80 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300226 | — | — | 1 | 8.60 |
| CHEMBL2079586 | — | — | 1 | 6.80 |
| CHEMBL607430 | — | — | 2 | 5.84 |
| CHEMBL607431 | — | — | 1 | 5.74 |
| CHEMBL607377 | — | — | 4 | 5.70 |
| CHEMBL310650 | — | — | 1 | 5.45 |
| CHEMBL1201203 | BENZTROPINE | 4.0 | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300226 | — | IC50 | = | 2.53 | nM | 8.60 |
| CHEMBL2079586 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL607430 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL607431 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL607377 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL310650 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL607377 | — | IC50 | = | 4087.0 | nM | 5.39 |
| CHEMBL607377 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL607430 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL607377 | — | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL1201203 | BENZTROPINE | IC50 | = | 24100.0 | nM | 4.62 |