Assay Detail
Binding
CHEMBL801384
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Inhibition of [3H]citalopram binding to the serotonin transporter in cynomolgus (macaca fascicularis) monkey caudate putamen.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.39 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84680 | — | — | 1 | 6.96 |
| CHEMBL88915 | — | — | 1 | 6.06 |
| CHEMBL89469 | — | — | 1 | 5.10 |
| CHEMBL103138 | — | — | 1 | 4.48 |
| CHEMBL101986 | — | — | 1 | 4.34 |
| CHEMBL318592 | — | — | 1 | - |
| CHEMBL100010 | — | — | 1 | - |
| CHEMBL103831 | — | — | 1 | - |
| CHEMBL323348 | DIMETHYL PHTHALATE | -1.0 | 1 | - |
| CHEMBL89662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84680 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL88915 | — | IC50 | = | 867.0 | nM | 6.06 |
| CHEMBL89469 | — | IC50 | = | 7990.0 | nM | 5.10 |
| CHEMBL103138 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL101986 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL318592 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL100010 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL103831 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL323348 | DIMETHYL PHTHALATE | IC50 | > | 100000.0 | nM | - |
| CHEMBL89662 | — | IC50 | - | nM | - |