Assay Detail
Binding
CHEMBL802161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards serotonin S1 receptor
8
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 1 (5-HT1) receptor (CHEMBL2095159) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.73 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287474 | — | — | 1 | 6.33 |
| CHEMBL34990 | — | — | 2 | 6.11 |
| CHEMBL1743803 | — | — | 3 | 5.78 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 5.30 |
| CHEMBL35184 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287474 | — | Ki | = | 465.0 | nM | 6.33 |
| CHEMBL34990 | — | Ki | = | 775.0 | nM | 6.11 |
| CHEMBL34990 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL1743803 | — | Ki | = | 1680.0 | nM | 5.78 |
| CHEMBL1743803 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL415 | CLOMIPRAMINE | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL1743803 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL35184 | — | Ki | > | 10000.0 | nM | - |