Assay Detail
Functional
CHEMBL802683
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Antagonistic activity was evaluated by using ACPD sensitive [3H]-glutamate binding assay in rat forebrain membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Forebrain |
| Subcellular | Membrane |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.60 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432038 | — | — | 1 | 8.00 |
| CHEMBL329920 | — | — | 1 | 7.30 |
| CHEMBL97574 | — | — | 1 | 7.15 |
| CHEMBL316521 | — | — | 1 | 6.28 |
| CHEMBL329953 | — | — | 1 | 5.59 |
| CHEMBL95444 | — | — | 1 | 5.29 |
| CHEMBL100208 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432038 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL329920 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL97574 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL316521 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL329953 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL95444 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL100208 | — | IC50 | > | 10000.0 | nM | - |