Assay Detail
Binding
CHEMBL803031
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding of [3H]citalopram to (SERT) serotonin transporter in rat striatum
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.05 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 6.88 |
| CHEMBL39262 | — | — | 1 | 6.86 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.13 |
| CHEMBL288128 | — | — | 1 | 6.13 |
| CHEMBL39259 | — | — | 1 | 6.06 |
| CHEMBL289028 | — | — | 1 | 5.93 |
| CHEMBL41558 | — | — | 2 | 5.73 |
| CHEMBL40607 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL39262 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL370805 | COCAINE | IC50 | = | 737.0 | nM | 6.13 |
| CHEMBL288128 | — | IC50 | = | 738.0 | nM | 6.13 |
| CHEMBL39259 | — | IC50 | = | 863.0 | nM | 6.06 |
| CHEMBL289028 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL41558 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL40607 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL41558 | — | IC50 | = | 8410.0 | nM | 5.08 |