Assay Detail
Binding
CHEMBL803032
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Inhibitory activity against Serotonin transporter using 0.2 nM [3H]paroxetine as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.94 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.98 |
| CHEMBL1790051 | — | — | 1 | 5.71 |
| CHEMBL3084343 | — | — | 1 | 4.73 |
| CHEMBL3085557 | — | — | 1 | 4.46 |
| CHEMBL610898 | — | — | 1 | 4.43 |
| CHEMBL21362 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370805 | COCAINE | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL1790051 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL3084343 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL3085557 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL610898 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL21362 | — | IC50 | = | 47800.0 | nM | 4.32 |