Assay Detail
Binding
CHEMBL803036
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Inhibitory activity against serotonin transporter (SERT) labeled with [3H]-citalopram in rat brain striatal membrane.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.78 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112928 | — | — | 1 | 7.12 |
| CHEMBL164303 | — | — | 1 | 7.07 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.06 |
| CHEMBL161437 | — | — | 1 | 6.74 |
| CHEMBL349023 | — | — | 1 | 6.71 |
| CHEMBL2112929 | — | — | 1 | 6.69 |
| CHEMBL350057 | — | — | 1 | 6.65 |
| CHEMBL2112930 | — | — | 1 | 6.63 |
| CHEMBL137718 | — | — | 1 | 6.57 |
| CHEMBL2112927 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112928 | — | IC50 | = | 75.8 | nM | 7.12 |
| CHEMBL164303 | — | IC50 | = | 85.7 | nM | 7.07 |
| CHEMBL281594 | VANOXERINE | IC50 | = | 86.6 | nM | 7.06 |
| CHEMBL161437 | — | IC50 | = | 180.4 | nM | 6.74 |
| CHEMBL349023 | — | IC50 | = | 194.1 | nM | 6.71 |
| CHEMBL2112929 | — | IC50 | = | 205.2 | nM | 6.69 |
| CHEMBL350057 | — | IC50 | = | 223.4 | nM | 6.65 |
| CHEMBL2112930 | — | IC50 | = | 231.8 | nM | 6.63 |
| CHEMBL137718 | — | IC50 | = | 271.2 | nM | 6.57 |
| CHEMBL2112927 | — | IC50 | = | 290.8 | nM | 6.54 |