Assay Detail
Binding
CHEMBL803041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]citalopram binding to serotonin transporter on rat striatal membranes.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.92 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.09 |
| CHEMBL137719 | — | — | 1 | 6.17 |
| CHEMBL138175 | — | — | 1 | 6.13 |
| CHEMBL338733 | — | — | 1 | 6.13 |
| CHEMBL137705 | — | — | 1 | 6.03 |
| CHEMBL137462 | — | — | 1 | 5.91 |
| CHEMBL335726 | — | — | 1 | 5.90 |
| CHEMBL135859 | — | — | 1 | 5.90 |
| CHEMBL135858 | — | — | 1 | 5.86 |
| CHEMBL132654 | — | — | 1 | 5.86 |
| CHEMBL33903 | — | — | 1 | 5.83 |
| CHEMBL343272 | — | — | 1 | 5.81 |
| CHEMBL135665 | — | — | 1 | 5.80 |
| CHEMBL33902 | — | — | 1 | 5.79 |
| CHEMBL34697 | — | — | 1 | 5.75 |
| CHEMBL341202 | — | — | 1 | 5.74 |
| CHEMBL20648 | — | — | 1 | 5.72 |
| CHEMBL132810 | — | — | 1 | 5.60 |
| CHEMBL137521 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL137719 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL138175 | — | IC50 | = | 741.0 | nM | 6.13 |
| CHEMBL338733 | — | IC50 | = | 743.0 | nM | 6.13 |
| CHEMBL137705 | — | IC50 | = | 927.0 | nM | 6.03 |
| CHEMBL137462 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL335726 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL135859 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL135858 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL132654 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL33903 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL343272 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL135665 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL33902 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL34697 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL341202 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL20648 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL132810 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL137521 | — | IC50 | = | 2880.0 | nM | 5.54 |