Assay Detail
Binding
CHEMBL803045
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relative affinity against serotonin transporter using RTI-55 as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.30 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343956 | — | — | 1 | 7.40 |
| CHEMBL23529 | — | — | 1 | 6.72 |
| CHEMBL141863 | — | — | 1 | 6.52 |
| CHEMBL222287 | IBOGAINE | 2.0 | 1 | 6.23 |
| CHEMBL341805 | — | — | 1 | 5.96 |
| CHEMBL336437 | — | — | 1 | 5.92 |
| CHEMBL139081 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343956 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL23529 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL141863 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL222287 | IBOGAINE | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL341805 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL336437 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL139081 | — | IC50 | = | 4300.0 | nM | 5.37 |