Assay Detail
Functional
CHEMBL803553
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Electrophysiological study in rat cortical slice model
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Heteroaryl analogues of AMPA. Synthesis and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.02 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94859 | — | — | 1 | 6.04 |
| CHEMBL310897 | — | — | 1 | 5.64 |
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 5.27 |
| CHEMBL441460 | — | — | 1 | 4.96 |
| CHEMBL318467 | — | — | 1 | 4.20 |
| CHEMBL328310 | — | — | 1 | 4.03 |
| CHEMBL317790 | — | — | 1 | - |
| CHEMBL97742 | — | — | 1 | - |
| CHEMBL94860 | — | — | 1 | - |
| CHEMBL98723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94859 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL310897 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL13378 | (R,S)-AMPA | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL441460 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL318467 | — | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL328310 | — | EC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL317790 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL97742 | — | EC50 | = | 550000.0 | nM | - |
| CHEMBL94860 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL98723 | — | EC50 | > | 1000000.0 | nM | - |