Assay Detail
Binding
CHEMBL803924
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Trishomocubanes, a new class of selective and high affinity ligands for the sigma binding site
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.45 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541347 | — | — | 1 | 8.16 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 7.69 |
| CHEMBL538300 | — | — | 1 | 7.52 |
| CHEMBL552794 | — | — | 1 | 7.46 |
| CHEMBL539310 | — | — | 1 | 7.24 |
| CHEMBL538057 | — | — | 1 | 7.10 |
| CHEMBL348313 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541347 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL660 | AMANTADINE | Ki | = | 20.25 | nM | 7.69 |
| CHEMBL538300 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL552794 | — | Ki | = | 34.5 | nM | 7.46 |
| CHEMBL539310 | — | Ki | = | 58.2 | nM | 7.24 |
| CHEMBL538057 | — | Ki | = | 78.7 | nM | 7.10 |
| CHEMBL348313 | — | Ki | = | 109.0 | nM | 6.96 |