Assay Detail
Functional
CHEMBL804137
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In vitro anti-oxytocic activity on isolated estrogen treated rat uteri with 0.5 mM Mg+2
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-O-alkyltyrosine derivatives of 1-deamino-arginine-vasopressin: highly specific and potent antidiuretic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.55 | 8.02 |
| pA2 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262753 | — | — | 1 | 8.02 |
| CHEMBL386483 | — | — | 1 | 7.71 |
| CHEMBL274636 | — | — | 1 | 7.64 |
| CHEMBL386280 | — | — | 1 | 7.64 |
| CHEMBL268780 | — | — | 1 | 7.40 |
| CHEMBL216742 | — | — | 1 | 7.40 |
| CHEMBL217307 | — | — | 1 | 7.05 |
| CHEMBL216989 | — | — | 1 | - |
| CHEMBL1429 | DESMOPRESSIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262753 | — | Kd | = | 9.55 | nM | 8.02 |
| CHEMBL386483 | — | Kd | = | 19.5 | nM | 7.71 |
| CHEMBL274636 | — | Kd | = | 22.91 | nM | 7.64 |
| CHEMBL386280 | — | Kd | = | 22.91 | nM | 7.64 |
| CHEMBL268780 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL216742 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL217307 | — | Kd | = | 89.13 | nM | 7.05 |
| CHEMBL216989 | — | Kd | = | 79432823.47 | nM | - |
| CHEMBL1429 | DESMOPRESSIN | pA2 | = | 167.0 | mg | - |